Monomeric IgM
IgM only exists as a monomer on
the surface of
B cells.
Monomeric
IgM has a very low affinity for antigen
Cm4
contains the transmembrane and cytoplasmic
regions.
These are removed by RNA
splicing to produce
secreted IgM
Polymeric IgM
IgM forms pentamers
and hexamers.
Cm3
binds C1q to initiate activation of the classical
complement pathway
Cm1
binds C3b to facilitate uptake of
opsonised
antigens by macrophages
Cm4
mediates multimerisation
(Cm3
may also be involved)
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